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Acetaminophen, also called paracetamol, drug used in the treatment of mild pain, such as headache and pain in joints and muscles, and to reduce fever. Acetaminophen is the major metabolite of acetanilid and phenacetin, which were once commonly used drugs, and is responsible for their analgesic (pain-relieving) effects. Acetaminophen in Pain management (377) Price when purchased online Sponsored $9.98 13.9 ¢/ea Advil Dual Action With Acetaminophen Pain and Headache Reliever Ibuprofen, Coated Tablets, 72 Count 4507 Save with Pickup Delivery 2-day shipping Best seller Sponsored $11.57 Motrin PM Caplets, 200 mg Ibuprofen & 38 mg Sleep Aid, 80 ct 132 Save with Know the milligrams in your pills. In acetaminophen products available over the counter, each pill may contain 325, 500, or 650 milligrams of the drug. Be extra cautious when taking 500 or 650 milligram pills. Stick to recommended doses. When taking acetaminophen, don't be tempted to add a little extra to the recommended dose. For pain or fever: For oral and rectal dosage forms (capsules, granules, powders, solution, suppositories, suspension, or tablets): Adults and teenagers—650 to 1000 milligrams (mg) every 4 to 6 hours as needed. Dose is based on form and strength. Carefully follow the label instructions for the maximum dose per day. Acetaminophen is a non-steroidal anti-inflammatory drug (NSAID) with a mechanism of action different from other NSAIDs. Its mode of action is not clearly understood, but it appears to inhibit cyclooxygenase (COX) in the brain selectively. This results in its ability to treat fever and pain. Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. 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