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According to the Sleep Health Foundation a melatonin supplement is best taken around one hour before going to bed, however, some people may begin to feel the effects as soon as 20 minutes after. Melatonin is a hormone secreted by the pineal gland to regulate circadian rhythm and the sleep-wake cycle. 1 A new prolonged-release melatonin tablet (Circadin) is TGA approved as monotherapy for short-term treatment (up to 3 weeks) of primary insomnia* characterised by poor quality of sleep in patients aged ≥ 55 years. 2 Buy on Amazon 3. ZzzQuil Pure Zzzs 2mg melatonin + herbal ingredients Vicks ZzzQuil Pure Zzzs go a couple of steps further than Vitafusion, adding valerian, lavender, chamomile and lemon balm to the melatonin. With just 2mg, it might suit people who want to try melatonin at a lower dosage. Tanning shots (injections under the skin) and nasal sprays contain chemicals such as melanotan I and melanotan II. 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