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This manuscript highlights the use of a new sustained-release low-dose minocycline 45 mg tablet, with or without azelaic acid, for the treatment of papulopustular rosacea. The extended-release formula allows for maintained efficacy despite lower doses. Lower maximum plasma concentration resulted in reductions in acute vestibular side effects. In 2006, extended-release minocycline became the first minocycline formula that was FDA approved for the treatment of inflammatory and non-nodular moderate to severe acne. 8 Minocycline is a tetracycline antibiotic that may be used to treat acne that is resistant to other antibiotics, as well as various other susceptible infections. It is marketed in Australia under the tradename Minomycin and the generic brand Akamin. 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