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Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study Vet Dermatol. 2019 Apr;30(2):91-e24.doi: 10.1111/vde.12727. Epub 2019 Feb 19. Authors Dramamine for dogs is one of the best choice drugs prescribed to manage motion sickness. What is Dramamine? Dramamine is an antihistamine drug prescribed to dogs to prevent and manage signs of motion sickness such as vomiting, nausea, dizziness, etc. It contains diphenhydramine as the active ingredient. They pride in providing quality pet medicines to pet owners. They have an easy online ordering service. Just select your medicine, enter its quantity and pay through a safe, encrypted network via your Master or Visa card. A flat airmail shipping fee of $6.95 is charged for any destination within the USA. 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