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Tramadol is another medication that has been commonly prescribed to treat pain in dogs; however, this is starting to fall out of favor with veterinarians. Studies have found that tramadol may not be as effective as originally thought. In fact, it was found to be ineffective at controlling pain associated with osteoarthritis in dogs. Tramadol is a strong pain medication used to treat moderate to severe pain that is not being relieved by other types of pain medicines. Tramadol is a synthetic opioid and acts in the brain and spine (central nervous system) to reduce the amount of pain you feel. The extended-release form of tramadol is for around-the-clock treatment of pain. Those prescribed tramadol had a higher risk of death than those prescribed anti-inflammatory medications. For example: naproxen: 2.2% of the tramadol group died vs. 1.3% of the naproxen group. diclofenac: 3.5% of the tramadol group died vs. 1.8% of the diclofenac group. etoricoxib: 2.5% of the tramadol group died vs. 1.2% of the etoricoxib group. Differences at a glance Tramadol Generic available —Yes Brand name —ConZip, Ultram Forms —Immediate-release tablets and extended-release tablets Strengths —Immediate release: 50 mg; extended... Diazepam, sometimes known by the brand name Valium, is a drug that can be used in dogs as an anti-anxiety medication, a muscle relaxant, a treatment for seizures, and medicine for other... The recommended dose of tramadol is 50-100 mg (immediate release tablets) every 4-6 hours as needed for pain. The maximum dose is 400 mg/day. To improve tolerance patients should be started at 25 mg/day, and doses may be increased by 25-50 mg every 3 days to reach 50-100 mg/day every 4 to 6 hours. Tramadol may be taken with or without food. What Is Tramadol? 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