fluoxetine versus vitex agnus castus extract in the treatment of premenstrual dysphoric disorder

Traditional uses. Fruits of V. agnus-castus have been used in the treatment of many female conditions, including menstrual disorders (amenorrhoea, dysmenorrhoea), premenstrual dysphoric disorder (PMDD), corpus luteum insufficiency, hyperprolactinaemia, infertility, acne, menopause, disrupted lactation, cyclic breast pain, cyclical mastalgia and inflammatory conditions, diarrhea and flatulence. 2) Migraines. In a 3-month study of 100 women with PMS and migraines, chasteberry treatment reduced the frequency of monthly migraines by more than 50 % in 42 % of patients. In addition, 57 % of patients given chasteberry had more than a 50 % lower frequency of monthly days with headaches [ 16 ]. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Fluoxetine inhibits the uptake of serotonin by a nerve cells (neurons) and helps people with depression, panic, anxiety, or obsessive-compulsive symptoms. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol . 2003;18(3):191-195.12672170 Berger D, Schaffner W, Schrader E, Meier B, Brattström A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Some experts recommend taking chasteberry on an empty stomach in the morning for maximal benefits. However, no studies have confirmed this finding. Various doses of chasteberry have been used in studies and practice. Traditional doses have ranged from 3.5-4.5 milligrams per day of dried extract to 600 milligrams three times per day of dried fruit. BACKGROUND The origin of the current practice of administering Vitex agnus-castus in menopause-related complaints is uncertain, but appears to be relatively recent.. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. M. Atmaca, S. Kumru. Dry extract of agnus castus fruit is an effective and. Milewicz, A et al. "[Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind. Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18(3):191-195.. Although V. agnuscastus has a low adverse-effect profile, women should avoid ingesting the herb while trying to become pregnant, during pregnancy, or while nursing. Vitex agnuscastus is an herb that has been used for hundreds of years in Europe for female reproductive system disorders, is well-tolerated, and has established efficacy in helping with some symptoms associated with premenstrual. ( 10) The herb chaste-tree ( Vitex agnus-castus) may help decrease PMDD symptoms to a similar extent as fluoxetine (an SSRI). ( 2 ) ( 6) 3. Manual therapies Acupuncture, light therapy, and massage have all been found to be helpful complementary therapies when managing PMDD. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Human Psychopharmacology 18(3), 191-195. Berger, D., Schaffner. W.,. Premenstrual syndrome and premenstrual dysphoric disorder: quality of life and burden of illness. Expert Review of Pharmacoeconomics & Outcomes Research 9(2), 157-170.. In addition, VAC extract was more efficacious than pyridoxine in the alleviation of PMS symptoms, whereas fluoxetine was superior than VAC in the alleviation of the psychological symptoms of PMS. VAC was generally very well tolerated, with most side effects being mild and transient. Approach Considerations Treatment of premenstrual dysphoric disorder (PMDD) includes both nonpharmacologic and pharmacologic therapies. Nonpharmacologic therapy includes aerobic exercise,... The success of medications in relieving symptoms varies among women. Commonly prescribed medications for premenstrual syndrome include: Antidepressants. Selective serotonin reuptake inhibitors (SSRIs) — which include fluoxetine (Prozac), paroxetine (Paxil, Pexeva), sertraline (Zoloft) and others — have been successful in reducing mood symptoms. Regarding PMDD, one study with 38 subjects reported clinical improvement in both the VAC and fluoxetine groups, with 57.9% of subjects responding to VAC, and 68.4% responding to fluoxetine. 10 The authors proposed that "fluoxetine may be more effective for psychological symptoms while VAC may be more effective for physical symptoms." مرکزی صفحہ Human Psychopharmacology: Clinical and Experimental Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder Human Psychopharmacology: Clinical and Experimental 2003 Vol. 18; Iss. 3 A review of 43 studies published from 1997 to 2016 concluded that Vitex agnus-castus is beneficial in treating infertility disorder in both men and women (as well as the treatment of PMS). The researchers hypothesized that chemical compounds in the plant influence the pituitary gland, which in turn decrease prolactin. مرکزی صفحہ Human Psychopharmacology: Clinical and Experimental Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder Human Psychopharmacology: Clinical and Experimental 2003 Vol. 18; Iss. 3 A review of 43 studies published from 1997 to 2016 concluded that Vitex agnus-castus is beneficial in treating infertility disorder in both men and women (as well as the treatment of PMS). The researchers hypothesized that chemical compounds in the plant influence the pituitary gland, which in turn decrease prolactin. Chaste tree (Vitex agnus-castus)-pharmacology and clinical indications. Phytomedicine. 2003;10(4):348-357. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003;18(3):191-195. Agnus-Castus Functions & Benefits In traditional times, this herb represented a reliable European remedy when it came to regulation and control of the female reproductive functions. Because of this, it was utilized for regularizing monthly periods or to treat conditions such as dysmenorrhea or amenorrhea. Abstract. Premenstrual dysphoric disorder (PMDD) is comprised of a cluster of affective, behavioral and somatic symptoms recurring monthly during the luteal phase of the menstrual cycle. The disorder affects 3-8% of menstruating women and represents the more severe and disabling end of the spectrum of premenstrual disorders, which includes. Botanical names: Vitex agnus castus How It Works Vitex contains several different constituents, including flavonoids, iridoid glycosides, and terpenoids. The whole fruit extract, rather than one of its individual constituents, appears to be necessary for the medicinal activity of vitex. 1 Vitex does not contain... Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used. In premenstrual dysphoric disorder, one study reported Vitex to be equivalent to fluoxetine, while in the other, fluoxetine outperformed Vitex. In latent hyper-prolactinaemia, one trial reported it to be superi-

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Treatment of premenstrual syndrome, premenstrual dysphoric disorder, and latent hyperprolactinemia, despite some methodological limitations. Therefore, considering the findings of both primary and secondary research, bromocriptine and vitex agnus castus have been shown to positively influence patients with hyperprolactinemia. Atmaca M, Kumru S, Tezcan E Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder . Hum Psychopharmacol. (2003) Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used for a range of female reproductive conditions in Anglo-American and European practice. The objective of this systematic review was to evaluate the evidence for the efficacy and safety of Vitex extracts from randomised, controlled trials investigating women's health.Eight databases were searched. Only two of the studies compared VAC to an SSRI, a well-established treatment for PMS and PMDD. In the first study (Atmaca et al, 2002), 41 women with PMDD were randomized to either fluoxetine or VAC for 2 months. In this study, a similar percentage of patients responded to fluoxetine (68.4%, n?=?13) and to VAC (57.9%, n?=?11). Chaste tree ( Vitex agnus castus) standardized extract, 400 mg daily before breakfast. Several studies suggest chaste tree or chasteberry may help reduce symptoms of PMS, including headache, irritable mood, and breast tenderness, however at least one study found it did not help reduce bloating. Konferans Bildirisi. EN TR PDF Vitex agnus-castus extract (Ze 440) improves symptoms in women with menstrual cycle irregularities Authors R. Eltbogen Department of Gynecology and Obstetrics, Bürgerspital, Solothurn, Switzerland M. Litschgi Consultant for Gynecology and Obstetrics Schaffhausen, Switzerland U. E. Gasser ClinResearch Ltd. Aesch, Switzerland The objective of the present study was to determine the efficacy and tolerability of a new solid formulation (capsules) of Agnolyt®(*)) in a randomized, controlled trial versus pyridoxine in women with PMTS over a period of three treatment cycles (Vitex agnus castus (VAC): 1 capsule + 1 placebo capsule/day, n = 90; pyridoxine (B6): 2 capsules day, n = 85). Vitex agnus castus L. (VAC) [Verbenaceae] is a deciduous shrub that is native to Mediterranean Europe and Central Asia. Traditionally, VAC fruit extract has been used in the treatment of many female conditions, including menstrual disorders (amenorrhoea, dysmenorrhoea), premenstrual syndrome (PMS), corpus luteum insufficiency, hyperprolactinaemia, infertility, acne, menopause and disrupted. Fluoxetine versus Vitex agnus castus extract in the treatment of. EN English Deutsch Français Español Português Italiano Român Nederlands Latina Dansk Svenska Norsk Magyar Bahasa Indonesia Türkçe Suomi Latvian Lithuanian český русский български العربية Unknown Studies have shown that the fruits of the chaste tree significantly reduce the symptoms of PMS, normalize the menstrual cycle, and lower prolactin levels. The use of Vitex is often preferable due to its high efficacy, long-term and short-term tolerance, and positive effect on the female reproductive system, including fertility. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003. Clinical trials have demonstrated that serotonin reuptake inhibitors (SRIs) and the extract of chaste berry are effective for the treatment of premenstrual dysphoric disorder (PMDD). Responder rates were 52% and 24% for active and placebo, respectively. Seven women reported mild adverse events (four active; three placebo), none of which caused discontinuation of treatment. Conclusions: Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003. Clinical trials have demonstrated that serotonin reuptake inhibitors (SRIs) and the extract of chaste berry are effective for the treatment of premenstrual dysphoric disorder (PMDD). The aim of the present study was to.

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Psychological symptoms improved in 68% of patients treated with Fluoxetine and mastalgia improved in 58% of patients treated with A. castus. A randomized, double-blind, placebo controlled trial and parallel group comparison was carried out in 170 women who were given A. castus or placebo for three consecutive cycles (active 86; placebo 84) ( 33 ). Vitex agnus -castus. in migrainous women with premenstrual syndrome: an open-label clinical observation. Acta Neurol Belg. 2013, 113:25-29 . Atmaca M, Kumru S, Tezcan E. Fluoxetine versus . Vitex agnus castus. extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol Clin Exp. 2003, 18:191-195 In another study, patients with PMDD were treated with fluoxetine and Vitex agnus-castus. The fluoxetine helped to treat psychological symptoms while the VAC extract reduced the physical symptoms ( 18 ). Efficacy of Vitex agnus-castus extract in premenstrual syndrome was assessed in China. Premenstrual syndrome involves a variety of physical, mental, and behavioral symptoms tied to a woman's menstrual cycle.; The acronym PMS stands for "premenstrual syndrome."; By definition, PMS symptoms and signs occur during the 2 weeks before a woman's period starts, known as the luteal phase of the menstrual cycle. Chasteberry is often used for irregularities of the menstrual cycle, infertility, premenstrual complaints, and cyclical breast pain. [ 1, 2] Some constituents, possibly the diterpene clerodadienols, bind to dopamine D2 receptors in the pituitary. [ 3] In low doses, chasteberry increases serum prolactin and it is a purported galactogogue; [ 4. 2 May 2019. Vitex agnus-castus is a herb, also known as Chaste Tree, Chasteberry and Monk's Pepper. It is mostly marketed for menstrual disorders, including symptoms of premenstrual syndrome and/or menopause, as well as for acne. Vitex agnus-castus is permitted for use in listed medicines in Australia. Listed medicines are identified by an. This review is based on published data on the fruits of the chaste tree (Vitex agnus-castus L.), a traditional medicinal plant used to treat premenstrual syndrome (PMS).The review summarizes and analyzes the existing literature on the chemical composition and pharmacological properties of the fruit extract and its individual chemical compounds. होम Human Psychopharmacology: Clinical and Experimental Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder Human Psychopharmacology: Clinical and Experimental 2003 Vol. 18; Iss. 3 With its emphasis on long-term balancing of a woman's hormonal system, vitex is not a fast-acting herb and is unlikely to give immediate relief to the discomfort associated with PMS. For premenstrual syndrome, frequent or heavy periods, vitex can be used continuously for four to six months. Approximately 30-40% of women report premenstrual syndrome symptoms that require treatment, while 3-8% of women during their reproductive years suffer from PMDD. The core PMD can be subdivided into predominantly somatic symptoms, predominantly psychological symptoms or mixed somatic and psychological symptoms. The menstrual cycle is a regular physiologic event for women that begins in adolescence and usually continues through late middle age. Women are able to self-treat for two common menstrual disorders: primary dysmenorrhea and premenstrual syndrome (PMS). In an open study of 20 healthy males, a special Agnus castus extract (BP1095E1, equivalent to 40 mg extract of chasteberry) was studied in doses of 120 mg, 240 mg and 480 mg daily in 3 divided doses. Each subject received placebo and each of the doses for 14 days, followed by 1 drug-free week. Although 6 of the studies involved small sample sizes (n < 50), all found fluoxetine to be effective in the treatment of PMDD. Conclusions: Despite limited data, fluoxetine 20 mg/d appears to be effective in the treatment of PMDD. However, adverse effects, particularly headaches and sexual dysfunction, are possible. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. (Q44388076) From Wikidata.. Description Also known as; English: Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. scientific article published in April 2003. Statements. instance of. scholarly. Gokaraju GR, Gokaraju RR, Gottumukkala VS, Somepalli V. Pharmaceutically active extracts of Vitex leucoxylon, a process of extracting the same and a method of treating diabetes and inflammatory diseases therewith. PCT Int. Appl. CODEN: PIXXD2 WO 2007029263 A1 20070315. 2007 [ Google Scholar] 56. Selective serotonin reuptake inhibitors — Selective serotonin reuptake inhibitors (SSRIs) are a highly effective treatment for the symptoms of PMS and PMDD. The SSRIs include fluoxetine (Prozac and Sarafem), sertraline (Zoloft), citalopram (Celexa), and paroxetine (Paxil). Latin Names: Vitex agnus-castus Background The chasteberry plant, also called chaste tree, is native to the Mediterranean region and Asia. The name "chasteberry" may reflect the traditional belief that the plant promoted chastity. Monks in the Middle Ages reportedly used it to decrease sexual desire. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. (PMID:12672170). Vitex is effective medicine for breast pain, irregular periods, premenstrual mood symptoms, and some types of acne. How does vitex work? Vitex promotes ovulation by boosting dopamine and lowering prolactin. It can also relieve symptoms of high prolactin such as premenstrual mood symptoms, breast pain, acne, and facial hair. Dos Do use for PMS Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Atmaca M, Kumru S, Tezcan E. Hum Psychopharmacol. 2003 Apr;18(3):191-5. Competing interests: No competing interests. 14 June 2011. Saul Berkovitz . Consultant Physician Early studies show long-termpercentage of patients responded to fluoxetine (68.4 supplementation is required for therapeutic effect. Sev-percent, n=13) versus Vitex (57.9 percent, n=11), not eral sources report response to treatment ranges froma statistically significant difference. Among these, extracts from the fruits of Vitex agnus castus (VAC, chaste tree) are the longest used and best investigated phytotherapeutics for PMS treatment. For the VAC BNO 1095 extract dopaminergic effects have been proven in animal and clinical trials [9], [10]. Bicyclic diterpenes isolated from VAC BNO 1095 extract have dopaminergic. In this study V. agnus-castus extract showed that fluoxetine was more effective for psychological symptoms while the extract diminishes the physical symptoms of premenstrual disorders.. Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. 2003; 18:191-5. Vitex agnus castus, one of the best-known adjuncts to fertility treatment, is beneficial for anovulatory cycles, hyperprolactinemia, hypothalamic dysfunction, hypothalamic-pituitary-ovarian (HPO) axis modulation, and promoting a regular and normal menstrual cycle. From: Textbook of Natural Medicine (Fifth Edition), 2020 Related terms: Pelvis Thank you for your participation! * Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18 (3):191-195. View abstract Berger D, Schaffner W, Schrader E, et al. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre- menstrual syndrome (PMS). Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxine Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxine Phytomedicine. 1997 Sep;4 (3):183-9. doi: 10.1016/S0944-7113 (97)80066-9. Authors Key points. Antidepressants that slow the reuptake of serotonin provide effective treatment for premenstrual dysphoric disorder (PMDD). These drugs alleviate the symptoms of PMDD more quickly than those of major depression, which means that women don't necessarily have to take the drugs every day. Hormone therapies provide additional options. Rank of variables had significantly difference in active and placebo group before and after the study (P<0.0001) also we noticed significant differences on the use of Vitex agnus in comparison with placebo (P<0.0001). Vitex agnus can be considered as an effective and well tolerated treatment for the relief of symptoms of mild and moderate PMS The objective of this study was to evaluate whether Vitex agnus castus is a safe and effective treatment for PMS and premenstrual dysphoric disorder (PMDD) and to discuss the implications of these findings for clinical practice. A systematic review of literature was conducted using PubMed and Scielo … Several clinical trials using Vitex agnus castus as a treatment for PMS symptoms showed it to be superior to placebo. Women with mild to moderate symptoms, including breast fullness, bloating, headache, menstrual pain, sleep disturbances, irritability and mood changes, felt significant improvement with the Vitex therapy compared to placebo.

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