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The cost for levothyroxine oral tablet (50 mcg (0.05 mg)) is around $15 for a supply of 30 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. In the case of this prescription, the difference in cost would be about $80 for a 90 day supply. Whereas with the Synthroid, the difference between the generic and name brand is $20-$25. Most Americans are unhappy about the cost of drug prices. In 2016, the U.S. spent $450 billion on prescription drug costs, and spending is projected to increase to $610 billion by 2021.. Even. Synthroid and Armour Thyroid are both brand-name drugs. There are currently no generic forms of either drug. Brand-name medications usually cost more than generics. An important factor to consider when purchasing desiccated thyroid medication is cost and performance, which typically go hand in hand. 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