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People who have sickle cell disease have a reduced life expectancy. Adults with the most severe forms of sickle cell disease have a life span that is 20 to 30 years shorter than people who don't have the condition. The national median life expectancy of people who have sickle cell disease is 42 to 47 years. A report from Blood, the Journal of the American Society of Hematology, showed that. Hydrea (hydroxyurea) is an antimetabolite medication used to treat chronic myeloid leukemia and locally advanced squamous cell head and neck carcinomas. It is also used to treat sickle cell disease. Hydrea works by inhibiting ribonucleotide reductase, an enzyme involved in DNA synthesis, to interfere with cancer cell production. HEB PHARMACY AS LOW AS $18.71 Use this coupon to get this price at any HEB PHARMACY location. Expand to see all locations within your area. 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