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Please see full prescribing information on each of our product pages for FDA-approved indications and dosage. Therapeutic Categories are not to be used as a replacement for reviewing FDA-approved prescribing information and are aligned to the American Hospital Formulary Service (AHFS) Therapeutic Classification System maintained by the American Society of Health-System Pharmacists (ASHP). Mechanism of Action of Losartan Potassium. It is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. 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