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The U.S. Food and Drug Administration (FDA) says over-the-counter (OTC) PPIs should only be taken for the 14-day course up to three times a year. Protonix (pantoprazole sodium) and Prilosec (omeprazole) are proton pump inhibitors (PPIs) used to treat gastroesophageal reflux disease (GERD) and a history of erosive esophagitis. Prilosec is also used to treat ulcers and frequent heartburn. Protonix is available by prescription while Prilosec is available over-the-counter (OTC) and as a generic. Omeprazole comes as capsules, tablets and as a liquid that you swallow. All types of omeprazole are available on prescription. You can buy 20mg tablets from pharmacies and supermarkets. Key facts Omeprazole starts to work within 2 to 3 days, but it may take up to 4 weeks for it to work fully. Omeprazole Common questions about omeprazole Brand names: Losec, Losec MUPS, Pyrocalm How does omeprazole work? When will I feel better? What if I do not get any better? Are there any long term side effects? 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