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This Tuesday, Aug. 15, 2017 photo shows an arrangement of pills of the opioid oxycodone-acetaminophen in New York. (AP Photo/Patrick Sison) Authorities say a key. The difference between the two is that generic oxycodone is an immediate-release version that lasts for about five to six hours, while OxyContin is a brand name version meant to last all day. On the street, a pill of generic oxycodone will cost around $12-$40. OxyContin can go for much higher, at around $50-$80 per pill, mostly due to its brand.
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