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Paroxetine is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, generalized anxiety disorder (GAD), social anxiety disorder (also known as social phobia), premenstrual dysphoric disorder (PMDD), and posttraumatic stress disorder. Paroxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant.. Paroxetine is used to treat depression, including major depressive disorder.. Paroxtine is also used to treat panic disorder, obsessive-compulsive disorder (), anxiety disorders, post-traumatic stress disorder (), and premenstrual dysphoric disorder ().. The Brisdelle brand of paroxetine is used to treat hot flashes. 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