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Prednisolone & Piroxicam in Dogs & Cats with Cancer - The Pet Oncologist About Publications Organise Online Consultation & Fees Submit Online Consultation Sample Consultation Reports Arrange A Consultation In Person Vet Education Handouts Arrange A Consultation In Person FAQ Useful Links Gallery For Vets Contact Subscribe This medication info sheet is meant to give you a good understanding of what prednisone and prednisolone are used for, how they work, and potential side effects in cats and dogs. These steroids are two distinct drugs; however, prednisone is converted to prednisolone in the liver. Always consult a veterinarian before giving your pet any. 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Prednisone/prednisolone is given by mouth or injection and is used on and off label to treat Addison's disease, inflammatory conditions, neoplasia (cancer), and immune-mediated diseases. Give this medication as directed by your veterinarian. Common side effects include increased drinking, increased urination, and increased appetite. Do not use in pets that are allergic to it, or pets with. The most common side effects associated with prednisone include increased drinking, urination, and appetite, and high doses of the drug causes mild salt retention. This can be problematic for dogs with congestive heart failure. At higher doses and for cases of long-term use, some possible side effects of prednisone can include vomiting. Prednisone is completely safe for your dogs when given in the right amount. It is even approved by the FDA for dogs. But, prednisone is not for all the dogs. If your dog is pregnant or diabetic, then avoid prednisone like the plague. 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