review of esomeprazole in the treatment of acid disorders

Esomeprazole (when dosed at 40 mg/day) is the first PPI to achieve more effective acid suppression than omeprazole 20 or 40 mg/day in pharmacologic studies and the first to yield higher GERD/EE. Esomeprazole oral capsule is a prescription drug that decreases the amount of acid the stomach makes. It can be used to treat GERD, esophagitis, and other conditions, and to prevent stomach ulcers. Intragastric acid suppression and pharmacokinelics of twice-daily esomeprazole: A randomized, three-way crossover study Article Aug 2004 Philip O Katz Donald O. Castell Y Chen Mark B Sostek... In vitro and in vivo data suggest that ilaprazole more potently inhibits gastric acid secretion compared to omepra-zole.13While the metabolism of ilaprazole into its major metabolite, ilaprazole sulfone, occurs primarily via CYP3A, it is minimally influenced by CYP2C19 polymorphism, resulting in a predictable dose-response relationship. Where's the nearest cash machine? ivermectin folyadk In his speech Friday, which was delivered before a conference held by the Brandeis International Business School, the official sketched out the factors that will drive the debate over the outlook for bond buying. He observed that there's a lot of uncertainty in how to read recent data, and a lot of uncertainty surrounding the outlook. Esomeprazole is a CYP2C19 inhibitor while vonoprazan inhibits both CYP2C19 and CYP3A4. Clopidogrel is a prodrug that must be converted to its active form by CYP2C19 and CYP3A4. Prasugrel is also a prodrug that relies on CYP3A4 primarily to convert to its active form. A single oral dose of tegoprazan 50 mg, vonoprazan 20 mg or esomeprazole 40 mg was administered at night in each period. Continuous intragastric pH was monitored at baseline and after each dosing. Results Sixteen healthy subjects (6 CYP2C19 extensive metabolizers, 5 intermediate metabolizers, 5 poor metabolizers) completed the study. Introduction. Drug prescription inappropriateness represents an issue of major interest in clinical practice, since it increases the prevalence of drug-induced harms, with consequences related to patients' health 1 and cost of care. 2 This is particularly true for elderly people, whose frailty makes the choice of the correct drug prescription even more difficult. 3 Nexium (Esomeprazole (Injection)) received an overall rating of 7 out of 10 stars from 137 reviews. See what others have said about Nexium (Esomeprazole (Injection)), including the effectiveness, ease of use and side effects.. I have excessive gastric acid upon eating stimulating food like spices and proteins. That can cause either diarrhea. Pantoprazole is marketed as being cheaper, and may be better for patients paying for their own medications. Esomeprazole (Nexium), a new and very potent PPI, was approved by the U.S. Food and Drug Administration (FDA) in 2001. Zegerid is a combination of omeprazole and sodium bicarbonate. Dexlansoprazole (Dexilant) was FDA approved in 2009. Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder characterized by the regurgitation of gastric contents into the esophagus. It is one of the most commonly diagnosed digestive disorders in the US with a prevalence of 20%, resulting in a significant economic burden in direct and indirect costs and adversely affects the quality of life[1][2]. GERD is caused by. Omeprazole works by preventing the secretion of acid in the stomach. The recommended dose is one capsule daily. From £9.99 View Product Lansoprazole Lansoprazole is an acid reflux treatment that helps to reduce the amount of acid produced in the stomach. It works by blocking the production of acid. The recommended dose is one capsule daily. Background: Esomeprazole is the most effective treatment for acid-related disorders and is widely used with enteric coating due to rapid degradation in the acidic environment. However, the enteric-coated formulation delays absorption and onset of action. To overcome this limitation, an immediate-release formulation containing esomeprazole 20 mg and Esomeprazole is a safe and effective PPI that is effective in the treatment of peptic ulcer disease and gastroesophageal reflux disease and has demonstrated acid control comparable to that of the other PPIs currently available. OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical efficacy, and safety of esomeprazole, a new proton-pump inhibitor (PPI). Get an overview of NEXIUM (esomeprazole magnesium granule, delayed release), including its generic name, formulation (i.e. pill, oral solution, injection, inhaled medicine) and why it's used. The medication in NEXIUM can be sold under different names.

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Esomeprazole is an effective, well tolerated treatment for managing GORD and for eradicating H. pylori infection in patients with duodenal ulcer disease. In 8-week double-blind trials, esomeprazole healed oesophagitis and resolved symptoms in patients with endoscopically confirmed erosive oesophagit … Proton pump inhibitors are commonly used clinical acid inhibitors, Minainet data shows that in 2022H1 China's public medical institutions terminal proton pump inhibitor sales exceeded 9 billion yuan, product TOP10 only exclusive variety of iprazole enteric-coated tablets achieved positive growth, brand TOP10 rabeprazole sodium enteric-coated capsules topped the list for the first time. A comparative, crossover study evaluated the effects of vonoprazan, a potassium competitive acid blocker, and esomeprazole on antiplatelet function of clopidogrel and prasugrel using a P2Y12 assay in 31 healthy Japanese subjects [11c]. Fourteen subjects were found to be CYP2C19 homo-extensive, 9 were hetero-extensive, and 8 were poor metabolizers. Omeprazole is also used in the treatment of hypersecretory conditions, such as Zollinger-Ellison syndrome, and is used with antibiotics to eradicate Helicobacter pylori (H. pylori). Omeprazole reduces the acidity (raises the pH) in the stomach by inhibiting the secretion of gastric acid. A new study has shed light on one of the long-term effects of proton pump inhibitors (PPIs). These drugs are commonly used to treat gastroesophageal reflux disease (GERD), heartburn, and peptic ulcers. PPIs (omeprazole, lansoprazole, esomeprazole, pantoprazole, and others) help reduce the amount of stomach acid made by glands in the lining of. オリジナルのイラストとかマンガとか描いてます。 新入荷〜（゜∀゜） (2012年03月19日) カテゴリー: I've just graduated cephalexin and amoxicillin allergy The unorthodox methods such as the Quantitative Easing, or Abenomix are well relying on the trickle-down economics to inject capital into the real economy, however the lending rates are reflection of an Economy's security, which particularly applies to the Small Businesses and Investors, so, when the Economy's security is low the. Chewing gum that contains bicarbonate has been shown to reduce acidity in the esophagus. Try herbal remedies. Chamomile, licorice, marshmallow, and slippery elm have been used for GERD. They're available in supplement and tincture form, as well as teas. Relieve stress. Stress may trigger symptoms of GERD in some people. 9. 9. 2014 8:22. Souhrn Jako refrakterní refluxní choroba jícnu je klasifikován stav, kdy i přes maximální léčbu refluxní symptomy přetrvávají nebo se mohou objevit nové a selhává hojení ezofagitidy. Za maximální léčbu je považováno podávání inhibitoru protonové pumpy v plné dávce 2krát denně. Nelze vyloučit, že. Omeprazole (brand name Prilosec) is a first-generation proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD), gastric ulcers, duodenal ulcers, upper gastrointestinal (GI) tract inflammatory conditions, eosinophilic esophagitis, and erosive esophagitis. Omeprazole is also used in the treatment of hypersecretory conditions, such as Zollinger-Ellison syndrome, and is. Acid reducers block acid by turning the body's acid pumps from on to off stopping acid before it starts ; PROVEN HEARTBURN TREATMENT - Compare to the active ingredient in Nexium 24Hr. The active ingredient in these delayed release capsules is Esomeprazole 20 mg, an acid reducer used to treat frequent heartburn that occurs 2 or more days a week Esomeprazole gastro-resistant capsules are used to treat the following conditions: Adults and adolescents aged 12 years and above 'Gastroesophageal reflux disease' (GERD). This is where acid from the stomach escapes into the gullet (the tube which connects your throat to your stomach) causing pain, inflammation and heartburn. Before the centralized procurement, the market of esomeprazole has been firm, with sales falling slightly by 0. 05% in 2020, 11. 05% in 2021 and 63. 21% in the first half of 2022, and the market share of the original manufacturer AstraZeneca fell from 100% in 2013 to 44. 70% in the first half of 2022 。 Ted States are living with some form of behavioral health issue. In fact, according to the National Alliance on Mental Illness, 50 percent of lifetime mental health illnesses begin by age 14. A magnifying glass. It indicates, "Click to perform a search". np. cw Normal controls, acid inhibition by rabeprazole was demonstrated to be significantly superior to omeprazole on a mg/mg basis. After the initial dose, rabeprazole (20 mg) inhibited acid secretion by 72% after 11 h and by 64% after 23 h compared with omeprazole (20 mg), which inhibited acid secretion by 49% and 38%, respectively (P<0.03). This. Omeprazole is indicated for the short-term treatment of peptic ulcer disease in adults, where most patients heal within four weeks. [1] Patients with duodenal ulcer disease and H. pylori infection that is active for up to one year may benefit from combination therapy of omeprazole with clarithromycin, amoxicillin, and metronidazole. A study of over 700 people found that esomeprazole was better at relieving heartburn symptoms than placebo (a pill with nothing in it). And another review of 8 studies found that esomeprazole 20 mg was better at improving symptoms of GERD than placebo. Omeprazole is also considered more effective than placebo. Cochrane Database of Systematic Reviews. 2016:CD010571. 2016. The gut microbiome: Potential. Acid-Suppressive Therapy With Esomeprazole for Relief of Unexplained Chest Pain in Primary Care: A Randomized,. Review article: current treatment options and management of functional dyspepsia. Proton Pump Inhibitors. Treatment for gastroesophageal reflux disease (GERD) usually consists of three stages. The first two stages include taking medications and making diet and lifestyle changes. As esomeprazole provides better control of intragastric pH [1][2][3] [4] [5][6] and has a higher degree of activity against H. pylori than other PPIs [8], it may be that, when combined with. Esomeprazole gastro-resistant capsules contain a medicine called esomeprazole, which belongs to a group of medicines called 'proton pump inhibitors'. They work by reducing the amount of acid that your stomach produces. Esomeprazole gastro-resistant capsules are used to treat the following conditions: Adults and adolescents aged 12 years and above Esomeprazole magnesium | C34H36MgN6O6S2 | CID 130564 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological"/> xt. bg. . . . . . It is the goal of this directory to help others find choices which lead to an improved quality of life. the GPI for Prozac 20mg capsules is also 58160040000120). Than all other regimens evaluated. Esomeprazole 40 mg daily, however, was comparable with lansoprazole 30 mg twice daily and superior to lansoprazole 30 mg once daily. INTRODUCTION Gastro-oesophageal reflux disease (GERD) is a common disorder characterized by heartburn symptoms, acid regurgitation or the presence of oesophageal lesions. Main content Search Results For : "成都育婴堂街18号院附近除甲醛公司【微信E12806】快速预 " Nexium injection is used to treat symptoms of gastroesophageal reflux disease ( GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Nexium I.V. is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Esomeprazole has a good tolerability profile and a low potential for drug interaction and correlates well with its more beneficial therapeutic efficacy over omeprazole and some of the other proton-pump inhibitors. Esomeprazole (S-isomer of omeprazole) demonstrates a better pharmacokinetic/pharmacodynamic profile than the racemic product omeprazole. Main results. Patients were allocated to receive either IV esomeprazole (n = 104) or IV pantoprazole (n = 101).The VAS scores before treatment and the changes at 30, 60, and 120 min are summarized in Table 2.For the VAS measurements at 30 and 60 min (target measurement), the median values of the VAS changes at 30 min when compared to 0 min were 26 mm (IQR = 17-38) in the esomeprazole group.

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Omeprazole, sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to other PPIs. Many gastrointestinal disorders, either functional or organic, are associated with some degree of sexual dysfunction. The main pathogenic mechanisms are: (i) the disease itself causing fatigue, anxiety or depression with a potential alteration of self-esteem; (ii) worry of transmitting a potential infectious agent through sexual activity; (iii) alteration of the endocrine mechanisms which are. Nexium/esomeprazole tablets are a type of medicine called proton pump inhibitors ( PPI ). PPI s were discovered in 1979 and have been in patient use for more than 30 years. They are safe and effective treatments for acid reflux/heartburn, and are also used for a range of other gastric and duodenal conditions. Esomeprazole, sold under the brand name Nexium among others, is a medication which reduces stomach acid. It is used to treat gastroesophageal reflux disease, peptic ulcer disease, and Zollinger-Ellison syndrome. Effectiveness is similar to other proton pump inhibitors (PPIs). It is taken by mouth or injection into a vein.. Common side effects include headache, constipation, dry mouth, and. Prescription Nexium: AstraZeneca manufactures this formulation that treats serious acid-related disorders. Generic Nexium: Several drugmakers manufacture esomeprazole, or generic Nexium. It is available in prescription and over the counter formulations. OTC Nexium 24HR: The U.S. Food and Drug Administration (FDA) approved this over-the-counter version of Nexium to treat chronic heartburn. We previously reported that the acid inhibition of esomeprazole 20 mg b.d. was less affected by CYP2C19 polymorphism than that of omeprazole 20 mg b.d., lansoprazole 30 mg b.d. and rabeprazole 10 mg b.d., with the result that esomeprazole was relatively effective even in RMs. 24 Nevertheless, esomeprazole still showed CYP2C19 genotype-dependent … Treatment options include lifestyle changes, medications, and sometimes surgery for those who do not improve with the first two measures. Lifestyle changes include not lying down for three hours after eating, lying down on the left side, raising the pillow/bedhead height, losing weight, and stopping smoking. Acute valvulitis in the setting of inflammatory and autoimmune disorders is well-known and mitral regurgitation is the most common valvular abnormality. Anti-inflammatory treatment is the mainstay of therapy. Institution of such treatment in a critically ill patient is challenging and patients should be closely monitored. Lamotrigine is a modern antiepileptic agent that has received approval for the prevention of depressive episodes in bipolar disorder. The pharmacological guidelines for treating bipolar disorder remain complex and recommend augmentation with lamotrigine for patients who respond partially to combined therapy with lithium and divalproex. INTRODUCTION ACMEROSEOLD 20 CAPSULE is a combination of Aspirin, Clopidogrel and Rosuvastatin which belongs to theroup of medicines called Antiplatelets and HMG-CoA reductase inhibitors respectively. ACMEROSEOLD 20 CAPSULE is indicated for the treatment of acute coronary syndrome, myocardial infarction (heart attack), angina (chest pain) or stroke (reduced blood supply to brain leading to. Esomeprazole may cause serious side effects. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; seizure (convulsions); kidney problems-- fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain; low magnesium-- dizziness, fast or irregular heart. Abstract: Proton-pump inhibitors (PPIs) are the drugs of choice for the treatment of gastroesophageal reflux disease (GERD). Esomeprazole is the latest PPI and was developed as the S-isomer of omeprazole as an attempt to improve its pharmacokinetic properties. Esomeprazole has been reported to have a somewhat higher potency in acid inhibition. Baking soda. As an antacid, baking soda can help temporarily neutralize stomach acid and provide relief. For adults and teenagers, dissolve 1/2 teaspoon in a 4-ounce glass of water. Talk to your. The usual doses used for GERD/EE in clinical trials have been 40 mg/day for short-term treatment and 20 or 40 mg/day for maintenance therapy. As part of triple therapy for H pylori,... The goals of pharmacotherapy are to prevent complications and to reduce morbidity in patients with gastroesophageal reflux disease (GERD). The agents used include antacids, H2 receptor antagonists,... The first oral Nexium (esomeprazole) formulation on the market was the delayed-release (DR) capsules (20 and 40 mg) approved for adult patients on 02/20/01 under NDA 21-153 for the treatment of... A patient is prescribed with esomeprazole for the treatment of GERD. Upon review of current medication use, the nurse noted that the patient is taking clopidogrel. The nurse warned the patient that esomeprazole: A. Have no evidence of potential interaction with clopidogrel B. Increase the effectiveness of clopidogrel Adult: 20 mg. . 5 oz. 11 Broadline for Cats 23 reviews £23. Omeprazole is also used as part of the treatment against an ulcer-causing bacteria in the stomach called. Background: Twice-daily dosing is increasingly used to improve gastric acid control, although not all proton-pump inhibitors are more effective when doses are split.Standard dose esomeprazole provides better gastric acid control than other standard dose proton-pump inhibitors. Aims: To compare the effect of standard dose esomeprazole (1 × 40 mg) with 20 mg b.d. on gastric acidity. This topic review will provide an overview of the mechanism of action, pharmacokinetics, administration, and adverse effects of PPIs. The use and efficacy of PPIs in specific acid-related disorders is presented separately. (See "Antiulcer medications: Mechanism of action, pharmacology, and side effects" .) INDICATIONS FOR PPI THERAPY

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Sandifer Syndrome In Babies: Causes, Symptoms And Treatment This rare condition results in exacerbated symptoms after the infant is fed. Medically reviewed by Dr. Wayne Hough , MBChB, MMed, FC Nexium (Esomeprazole) Reviews. Esomeprazole (the active ingredient for Nexium) is an effective medicine for the treatment of acid reflux. 9.8 / 10. 5: 20: 4: 2: 3: 0: 2: 0: 1: 0:. Easy to order process and payment method. Kept up to date with stage of order and arrival date. Would highly recommend." We and our partners store and/or access information on a device, such as cookies and process personal data, such as unique identifiers and standard information sent by a device for personalised ads and content, ad and content measurement, and audience insights, as well as to develop and improve products. Gastroesophageal Reflux Disease (GERD) is characterized by acid and bile reflux in the distal oesophagus, and this may cause the development of reflux esophagitis and Barrett's oesophagus (BE). The natural histological course of untreated BE is non-dysplastic or benign BE (ND), then lowgrade (LGD) and High-Grade Dysplastic (HGD) BE, with the expected increase in malignancy transfer to. Common side effects may include: headache; diarrhea; nausea, stomach pain, gas, constipation; or. dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Bundle contains 10 documents. 1. ATI Capstone Pharmacology latest 2023 questions and answers. 2. ATI Capstone- Fundamentals Pre-Assessment test verified. 3. ATI - Comprehensive Practice 2023 A test. 4. ATI Capstone Fundamentals questions and answers rated A solutions. Esomeprazole is the S-isomer of omeprazole. Compared with omeprazole, esomeprazole undergoes less first pass metabolism by CYP2C19 in the liver, and therefore has a superior AUC (area under the concentration-time curve) to omeprazole 23 and yields more potent acid inhibition. The medication is useful in the treatment of oesophagus and stomach problems such as ulcers, hyper acidity, and acid reflux. It works by effectively reducing the level of acid the stomach produces hence relieving painful symptoms such as persistent coughing, heartburns, and difficulty swallowing. How does Esomeprazole work? Esomeprazole, the S-isomer of omeprazole, is the first proton pump inhibitor to be developed as a single optical isomer. It provides better acid control than current racemic proton pump inhibitors and has a favourable pharmacokinetic profile relative to omeprazole. In large well designed 8-week trials in patients with erosive oesophagitis, esomeprazole recipients achieved significantly higher. The transitions of m/z 346.1 to 198.2 for esomeprazole and m/z 237.2 to 194.2 for carbamazepine. The peak areas for all components were automatically integrated by Analyst software version 1.5.1.i Esomeprazole was separated by gradient elution, which is con-sisted of mobile phase A 0.1% formic acid and B 0.1% formic acid in acetonitrile. Adult: Erosive reflux oesophagitis: 40 mg once daily. Symptomatic treatment: 20 mg once daily. Doses are given via slow inj over at least 3 minutes or infusion over 10-30 minutes. Treatment duration: Up to 10 days. Switch to oral therapy as soon as possible. Child: 1-11 years Erosive reflux oesophagitis: <20 kg: 10 mg once daily; ≥20 kg: 10. The aim of this review is to give an updated perspective about the methods for chemical modifications of hyaluronic acid (HA) toward the development of new applications in medical devices and material engineering. After a brief introduction on chemical, structural and biological features of this important natural polysaccharide, the most important methods for chemical and physical. Omeprazole is a member of a new class of substituted benzimidazoles. These agents inhibit the proton pump in the gastric parietal cell, blocking the final step in the gastric acid secretory. Study with Quizlet and memorize flashcards containing terms like A male client arrives at his sick call reporting chronic abdominal pain. Having a 40-pack year history, he reports his smoking has decreased to approximately 20 packs/year. The health care provider, after thorough assessment and evaluation and labs, prescribes a treatment regimen for a duodenal ulcer caused by H. pylori infection. This narrative review synthesises and presents the current evidence from systematic reviews, meta-analyses, and latest clinical trials on N-acetylcysteine for addiction and substance abuse, schizophrenia, obsessive-compulsive and related disorders, and mood disorders. Nexium (esomeprazole) is a proton pump inhibitor (PPI) available to people with stomach acid-related conditions like gastroesophageal reflux disease (GERD). In addition to treating GERD in adults and children, Nexium can help prevent stomach ulcers caused by medications, infection, and other causes. 1. Esomeprazole comes in delayed-release. Valproic acid's primary use is as an anti-seizure medication, as well as in migraine, bipolar, mood, and anxiety disorders. Recent work has also demonstrated its efficacy as adjuvant therapy in HIV, cancer, and neurodegenerative diseases as its histone deacetylase (HDAC) inhibition property. PPIs work by blocking and reducing the production of stomach acid. This gives any damaged esophageal tissue time to heal. PPIs also help prevent heartburn, the burning sensation that often... Esomeprazole sodium can affect the results of certain medical tests. Tell any doctor who treats you that you are using Nexium Injection. Store Nexium injection at room temperature away from moisture, heat, and light. Store mixed injection at room temperature and use it as soon as possible. Nach einem Cochrane-Review ist Macrogol für die Behandlung der. Scolapio JS (2004) Gastric motility disorders: management that optimizes nutritional status. J Clin Gastroenterol 38:549-557. Harthon C, Jörgensen L, Carling L, Modin S, Stubberöd A, Toth E, Lind T (2005) Daily treatment with esomeprazole is superior to that taken on. Esomeprazole (Esoz (20mg)) is a proton pump inhibitor (PPI), prescribed for gastroesophageal reflux disease (GERD). With amoxicillin and clarithromycin it is used for treatment of Helicobacter... Esomeprazole Acid Reducer Capsules - 42ct - up & up™ $15.59When purchased online In Stock Add to cart About this item At a glance Gluten Free HSA/FSA Eligible Highlights Compare to the active ingredient of Nexium 24 HR Treats frequent heartburn occurring 2 or more days a week One capsule per day for 14-day course treatment MOT DU PRESIDENT. Après une longue attente, et à l'instar des autres conseils régionaux du royaume, le Conseil Régional des Architectes de l'Oriental vient de mettre en li Pantoprazole. It is a prescription drug that is available as the brand-name drug Protonix. This drug is a proton pump inhibitor that inhibits gastric acid secretion. By reducing the production of acid, it allows the esophagus and stomach to heal. US Food and Drug Administration approved it in February 2000. Esomeprazole: A Review of its Use in the Management of Acid-Related Disorders in the US Authors: Lesley J Scott Christopher J Dunn Gordon Mallarkey SAGE Publishing Ltd Miriam L Sharpe... Proton pump inhibitors (PPIs) are the most potent inhibitors of gastric acid secretion available, and they are effective for treating all acid-related disorders Esomeprazole is indicated for the treatment of gastroesophageal reflux disease in adults and children, risk reduction of NSAIDs-associated gastric ulcer, Helicobacter pylori eradication … Foods that cause acid reflux in adults; importance of markup and markdown; best staff stance warframe; 2925 aventura blvd suite 100; call it what you want piano chordsadeyemi fm22 work permit; five points gallery durham; montreal canadiens captain 2022; suction cup won't stick to windshield; foods that cause acid reflux in adults Therapy for gastric acid-related disorders, partic-. Review of esomeprazole in the treatment of acid. histamine stimulated human gastric acid secretion. Gut 1984; disorders. Expert Opin. Esomeprazole is a 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium salt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome. This medicine is used for the treatment of conditions that are caused by stomach acid, like - gastroesophageal reflux disease, duodenal and stomach ulcers, and the Zollinger-Ellison syndrome. Moreover, it is used to prevent ulcers caused by Helicobacter pylori bacteria and nonsteroidal anti-inflammatory drugs.