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Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking. The efficacy of SEROQUEL for the treatment of depressive episodes associated with bipolar disorder was established in 2 identical 8-week, randomized, double-blind, placebo-controlled studies (N=1045). These studies included patients with either bipolar I or II disorder and those with or without a rapid cycling course. Quetiapine XR - Seroquel XR®. at Point-of-Sale . Suggests a diagnosis code if one is not submitted on the pharmacy claim. Applies to FFS and All MCOs as of 10/1/18. Premenstrual Dysphoric Disorder.. Generalized Anxiety Disorder. F41.1. Panic Disorder with Agoraphobia. F40.01. Several of these antipsychotic medications, including quetiapine (Seroquel), have become particularly popular for use in treating depression. 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