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Spironolactone is one of our GMP-Approved Pharmaceutical Ingredients along with Amphotericin B, Bacitracin, Cyclosporine, etc. It is a white to off-white powder, a potassium-sparing diuretic that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone, also known as aldactone, is a diuretic drug used to treat hormonal acne, along with other conditions such as polycystic ovary syndrome (PCOS), high blood pressure and congestive heart failure. Women with persistent hormonal acne often have recurring inflammation along the jawline and neck area, caused by increased sebum. In Portugal, it is possible to purchase estradiol over the counter at some pharmacies. Look around. We're not sure exactly what brand or type, but this can be a legitimate way to get estradiol without a prescription in Portugal. Spironolactone is not available OTC in Portugal. 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