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There is a greater likelihood of misusing tramadol if you have a family or personal history of substance dependency or mental illness. Always follow your doctor's instructions when using any prescription drug. Never mix tramadol with other. Tramadol is from a group of medicines called opiates, or narcotics. It acts on pain receptors in the central nervous system and the brain to block pain signals to the rest of the body. It also works in your brain to stop you feeling pain messages. When will I feel better? That is why advice on face to face and remote prescribing is integrated throughout the guidance. We also set out things to consider if prescribing to patients who are overseas or if prescribing unlicensed medicines. This guidance was published on 18 February 2021 and came into effect on 5 April 2021. This guidance was updated on 15 March 2022. 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