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Here, a steady-state trough concentration of 15 mg/L guarantees an AUC of 360 in 24 hours (dark blue) and because the trough is the lowest concentration of a drug, we can expect the corresponding AUC to be at least 400 thanks to the peak (light blue). Therefore, we can feel confident that vancomycin trough concentrations between 15 to 20 mg/L. Buy Vancomycin (Generic Firvanq, Vancocin) Online | Blink Health vancomycin vancomycin hcl Vancomycin is used to treat a certain intestinal condition (colitis) that may rarely happen after treatment with antibiotics. This condition causes diarrhea and stomach/abdominal discomfort or pain. Vancomycin Pharmacokinetics Pharmacokinetics (PK) can be used to individualize vancomycin dosage based on goal serum levels and AUC. Before applying kinetics in a clinical setting it's important to understand PK concepts and equations. Vancomycin monitoring guidelines recommend targeting an AUC range of 400-600 mg*hr/L. 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