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Prescription topical anti-viral creams can reduce the severity and duration of a cold sore. The most effective are penciclovir and acyclovir and should be started ASAP at the first signs of a prodrome, per Dr. Shainhouse.. For Cold Sores: "Zorvirax duo honestly works. Prescription cold sore medicine zovirax. Acyclovir - Cold Sore Treatment Fast, Effective treatment for current and future outbreaks of cold-sores. PRICE CHECKER Quantity .99 Includes Free Private Prescription Start Consultation Our Prices Acyclovir 400mg 12 (1 outbreak) - .99 24 (2 outbreaks) - .99 36 (3 outbreaks) - .99 180 (suppression) - .99. Valacyclovir is an antiviral drug prescribed to treat chickenpox, cold sores, herpes zoster, or genital herpes. Since valacyclovir is classified as an antiviral drug, it's not used to cure infections, but rather to slow down the growth of the infection itself. What are the uses for valacyclovir? Valacyclovir can be used to treat cold sores. Zovirax is a branded tablet used for outbreaks of cold sores and genital herpes. Cold sores and genital herpes are caused by a virus in the skin called herpes simplex (HSV). Zovirax can fight the outbreak of HSV, as it contains a medication called aciclovir, which can speed up the healing process and help with symptoms. Pickup Delivery 2-day shipping. $29.88. Zilactin Early Relief Cold Sore Oral Pain Treatment Gel, 0.25oz, 3-Pack. 3+ day shipping. $14.12. $26.15/fl oz. Equate 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid), 50 mcg Per Spray, Full Prescription Strength, Non-Drowsy, 0.54 fl. Oz. 825. Acyclovir Cream Generic name: Acyclovir Cream [ ay-SYE-kloe-veer ] Brand name: Zovirax Drug class: Topical antivirals Medically reviewed by Drugs.com. Last updated on May 27, 2022. Uses Before taking Warnings Side effects Overdose Dosage Uses of Acyclovir Cream: It is used to treat cold sores . 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