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Zantac 360 (famotidine tablet, film coated) is an acid reducer used to relieve heartburn associated with acid indigestion and sour stomach and to prevent heartburn associated with acid indigestion and sour stomach brought on by eating or drinking certain food and beverages. Zantac 360 is available over-the-counter without a prescription. Zantac contains ranitidine while Zantac 360 contains famotidine. Both of these active ingredients (ranitidine and famotidine) are in the same class of drugs, known as H2-blockers (or more specifically, histamine type-2 receptor antagonists) and work the same way. There is very little difference between them in terms of how well they work. Ranitidine, brand name Zantac, is now marketed as Zantac 360, which contains a different active ingredient (famotidine). Famotidine is in the same class as ranitidine and works the same way... Zantac 360 starts working in as little as 15 minutes and controls stomach acid production for up to 12 hours*. 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