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Depending on the dosage, a 30-day supply costs between $4.00 and $25. The generic form of Zoloft is usually well covered by insurance. Even if it isn't, it's generally not very expensive so cost isn't prohibitive." Despite it seeming like antidepressants are... Enterprise. Fintech. Policy Zoloft is also in the top 20 of all medications prescribed. Perhaps this is because of its' efficacy, safety, tolerability, and low-cost generic form, as Dr. Meltzer-Brody explained. (Zoloft) Side effects and other attributes used in patient selection Tends to cause fewer arousal and insomnia effects common with SSRIs;. cost/mo f 300-400 mg/d $31-31 generic 600 mg/d $46 generic 150-225 mg/d $96 -$184 375-450 mg/d $280 -$288 60 mg QHS; TBA in final release 60 mg BID Dosing for youthful, Generic Paxil (paroxetine) and generic Zoloft (sertraline) are usually covered under most insurances as well as Medicare Part D. 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